WDHD1

WD repeat and HMG-box DNA binding protein 1 is a protein in humans that is encoded by the WDHD1 gene. [5]

WDHD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D7L
Identifiers
Aliases	WDHD1, AND-1, CHTF4, CTF4, AND1, WD repeat and HMG-box DNA binding protein 1
External IDs	OMIM: 608126 MGI: 2443514 HomoloGene: 56019 GeneCards: WDHD1
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.2-q22.3 Start 54,938,949 bp[1] End 55,027,105 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 47,240,944 bp[2] End 47,276,857 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • DNA binding • chromatin binding • RNA binding • RNA polymerase binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cytoplasm • cell nucleus • nucleoplasm • chromosome, centromeric region • replication fork protection complex • nuclear replication fork Biological process • RNA processing • regulation of chromosome organization • heterochromatin maintenance • regulation of transcription from RNA polymerase II promoter • mitotic cell cycle • DNA-dependent DNA replication • DNA repair • cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11169	218973
Ensembl	ENSG00000198554	ENSMUSG00000037572
UniProt	O75717	P59328
RefSeq (mRNA)	NM_001008396 NM_007086	NM_172598 NM_001360532
RefSeq (protein)	NP_001008397 NP_009017	NP_766186 NP_001347461
Location (UCSC)	Chr 14: 54.94 – 55.03 Mb	Chr 14: 47.24 – 47.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].