Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)

Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) (EC 2.5.1.89) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 7 isopentenyl units).[1] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate + 7 isopentenyl diphosphate 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)
Identifiers
EC number2.5.1.89
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is involved in the biosynthesis of the glycosyl carrier lipid in some archaebacteria.

References

  1. Hemmi H, Yamashita S, Shimoyama T, Nakayama T, Nishino T (January 2001). "Cloning, expression, and characterization of cis-polyprenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus acidocaldarius". Journal of Bacteriology. 183 (1): 401–4. doi:10.1128/JB.183.1.401-404.2001. PMC 94892. PMID 11114943.
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