Triacylglycerol—sterol O-acyltransferase

In enzymology, a triacylglycerol---sterol O-acyltransferase (EC 2.3.1.77) is an enzyme that catalyzes the chemical reaction

triacylglycerol + a 3beta-hydroxysterol diacylglycerol + a 3beta-hydroxysterol ester
triacylglycerol-sterol O-acyltransferase
Identifiers
EC number2.3.1.77
CAS number80487-96-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are triacylglycerol and 3beta-hydroxysterol, whereas its two products are diacylglycerol and 3beta-hydroxysterol ester.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is triacylglycerol:3beta-hydroxysterol O-acyltransferase. This enzyme is also called triacylglycerol:sterol acyltransferase.

References

    • Zimowski J, Wojciechowski ZA (1981). "Acyl donors for sterol esterification by cell-free preparations from Sinapis alba roots". Phytochemistry. 20 (8): 1799–1803. doi:10.1016/0031-9422(81)84007-1.


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