Thetin—homocysteine S-methyltransferase
In enzymology, a thetin-homocysteine S-methyltransferase (EC 2.1.1.3) is an enzyme that catalyzes the chemical reaction
- dimethylsulfonioacetate + L-homocysteine S-methylthioglycolate + L-methionine
| thetin-homocysteine S-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.3 | ||||||||
| CAS number | 9029-76-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are dimethylsulfonioacetic acid and L-homocysteine, whereas its two products are S-methylthioglycolic acid and L-methionine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is dimethylsulfonioacetic acid:L-homocysteine S-methyltransferase. Other names in common use include dimethylthetin-homocysteine methyltransferase, and thetin-homocysteine methylpherase.
References
- KLEE WA, RICHARDS HH, CANTONI GL (1961). "The synthesis of methionine by enzymic transmethylation. VII Existence of two separate homocysteine methylpherases on mammalian liver". Biochim. Biophys. Acta. 54 (1): 157–64. doi:10.1016/0006-3002(61)90948-9. PMID 14456704.
- MAW GA (1956). "Thetin-homocysteine transmethylase; a preliminary manometric study of the enzyme from rat liver". Biochem. J. 63 (1): 116–24. PMC 1216008. PMID 13315256.
- MAW GA (1958). "Thetin-homocysteine transmethylase; some further characteristics of the enzyme from rat liver". Biochem. J. 70 (1): 168–73. PMC 1196643. PMID 13584318.
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