The Shakiest Gun in the West

Jesse W. Haywood (Don Knotts) graduates from dental school in Philadelphia in 1870 and goes west to become a frontier dentist. As a "city slicker", he finds himself bungling in a new environment.

On his way west, the stagecoach is held up and robbed by two masked bandits. A posse catches one of them, Penelope "Bad Penny" Cushing (Barbara Rhoades).

Facing prison, Penelope is offered a pardon if she will track down a ring of gun smugglers that also involves a local Indian tribe. Because the wagon train she plans to accompany will not permit single women to join, she tricks Haywood into a sham marriage as a disguise.

Jesse, excited for his wedding night and not realizing that his marriage is a sham, looks for Penelope, who is investigating the crates of "Bibles" that the Preacher and his minion have in their tent. Jesse startles Penelope who alerts the camp. Her investigation foiled, she goes to bed dragging along her bungling husband.

As the wagon train draws near the town, Indians attack. As Jesse fumbles with his six-shooter, Penelope expertly shoots the attackers. Jesse, believing that he was responsible, is proud of his accomplishment and is treated as a hero by the wagon train and the entire town that hears of his deeds.

The Preacher and his minion, believing Jesse to be the undercover federal agent, hires the local outlaw Arnold the Kid to challenge Jesse to a gunfight. In the yard as Jesse practices for his gunfight, Penelope meets with her contact in town. Around the corner, Arnold listens for Jesse to use up his rounds and after the sixth shot challenges Jesse, even offering him the first shot. Penelope, feeling pity for Jesse, kills Arnold from the window.

Haywood inadvertently becomes the legendary "Doc the Heywood" after he guns down "Arnold the Kid" and performs other exploits (all with covert assistance from Penny).

Later that night, as Penelope leaves to search the church where the Preacher resides, Jesse confronts her, demanding where she is going. Penelope explains her situation and Jesse offers his help, believing himself to be a crack shot. Penelope, not wanting Jesse to hurt himself, tells him the truth about her assistance on the wagon train and with Arnold. Penelope leaves, apologizing to Jesse, who is now heartbroken.

Penelope investigates the church and is kidnapped by the Preacher and his minion, who take her to the Indian village outside of town. Meanwhile, Jesse walks into the saloon and admits the truth of his deeds to the town...who now find him a joke. As a drunken Jesse stumbles out of the saloon, he sees Penelope being taken out of town by the Preacher. Jesse follows them to the Indian village to save Penelope.

In disguise as a squaw, Jesse maneuvers around the village and frees Penelope, suggesting they wait for the entire village to get even more drunk. Eventually Jesse is discovered and the Preacher and his minion challenge Jesse to a gunfight. Jesse is confident, as he knows Penelope is armed and ready in the shadows. As Penelope sets her sights, she is grabbed by two Marshals who sneaked into the village to save her. Two gun shots rang out and Penelope, crestfallen, leaves the village. Jesse however stands victorious with the Preacher and his minion shot dead. Jesse is surrounded by the rest of the village and appears doomed.

Back at the town, the gates are barred and the townspeople prepare for a battle. To everyone's surprise, Jesse rides with the Chief at his side and the remainder of the tribe behind them. Jesse has made peace with the Chief, using his dentistry skills to replace his missing teeth and orders him a rare steak. Jesse and Penelope reunite and hug.

There are a couple of scenes which parody similar scenes in The Man Who Shot Liberty Valance with John Wayne and James Stewart. The stagecoach holdup scene is the first encounter that both city dudes have with the "Wild West". In the gunfight scene, both "dudes" are about to be shot down in duels with experienced gunfighters, when they are saved by one of the good guys, who shoots the villain from a hidden position, which makes the shooting look like the underdog won a legitimate gunfight.

• Don Knotts as Dr. Jesse W. Heywood
• Barbara Rhoades as Penelope 'Bad Penny' Cushings
• Jackie Coogan as Matthew Basch
• Burt Mustin as Old Artimus
• Don 'Red' Barry as Rev. Zachary Gant (as Donald Barry)
• Ruth McDevitt as Olive
• Frank McGrath as Mr. Remington
• Terry Wilson as Welsh
• Carl Ballantine as Abel Swanson

The film was originally released on VHS in 1988 by GoodTimes Home Video and re-released on VHS in 1996 by MCA Home Video. It was later released on DVD in 2003 by Universal Pictures.

The plot of the film Beethoven's 3rd revolves around a DVD copy of The Shakiest Gun in the West, and, consequently, this film is discussed during the Beethoven film.

The Shakiest Gun in the West has been cited as one of the main influences for the 2011 animated film Rango.

• List of American films of 1968

• The Shakiest Gun in the West on IMDb 
• The Shakiest Gun in the West at the TCM Movie Database
• The Shakiest Gun in the West at AllMovie
• The Shakiest Gun in the West at the American Film Institute Catalog
• New York Times review