Thatteem Mutteem

The recurring theme is the quarrel between the Mayavathyamma and her daughter-in-law Mohanavally, and the struggle of the kids and Arjunan to resolve it. Although the daughter-in-law has a strong distaste towards the mother-in-law, they share a mutual respect for one another.

They are frequently visited by Arjunan's best friend, Kamalahasanan, Mohanavalli's mother, Komalavally, and Arjunan's sister Kokila, his sister and her children Bhavani and Bharathi.

Arjunan's millionaire brother Sahadevan, his wife Vidhubala and their three children arrives from the United States. Meenakshi is married to Aadhi Shankaran, son of Pravasi Shankaran and Vasavadatha.

• K. P. A. C. Lalitha as Mayavathi Amma: Mother of Arjunan, Sahadeven, Kokila, and Nakulan. She is the head of the family and the only breadwinner.
• Manju Pillai as Mohanavally: Homemaker mother of Meenakshi and Kannan, Arjunan's wife and Komalavally's daughter.
• Jayakumar Parameswaran Pillai as Arjunan: A lazy government employee. Father of Meenakshi and Kannan and husband of Mohanavally. He also portrays Krishnan Vakkeel, father of Arjunan, Sahadeven, Kokila, and Nakulan. Arjunan frequently writes unappreciated poems.
• Bhagyalakshmi Prabhu as Meenakshi: Daughter of Arjunan and Mohanavally, Aadhi's wife, and Sahadevan's niece. She is a nursing graduate and now a homemaker.
• Sidharth Prabhu as Kannan: Son of Arjunan and Mohanavally, Sahadevan's nephew. He also portrays a young Krishnan Vakkeel.
• Sagar Suryan as Aadhi Sankaran / Aadhi (Season 2): A lazy engineering post-graduate, husband of Meenakshi and the only son of Pravasi Shankaran and Vasavadattha.
• Naseer Sankranthi as Kamalasanan / Kamalu: A self-proclaimed politician. Arjunan's best friend and Sahadevan's classmate.
• Rajesh Paravoor as Sahadevan / Sahu (Season 2): Arjunan's younger brother, and father of Chikku, Chinnu, and Chinnan. He also portrayed the role of Doctor Parelal (Season 1 Ep:122).
• Shalu Kurian as Vidhubala / Vidhu (Season 2): Sahadevan's wife and Arjunan's younger sister-in-law, and mother of Chikku, Chinnu, and Chinnan.

• Veena Nair as Kokila Shishupalan / Kokila: Arjunan's younger sister.
• Maneesha K. Subrahmaniam as Vasavadattha: Aadhi's mother and Shankaran's wife. She is a homemaker who won a lottery ticket.
• Nandakishor Nellickal as Pravasi Shankaran: Aadhi's father and Vasavadattha's insane husband.
• Anumol R. S. as Chakki: Aadhi's cousin.
• Parvathy Lal as Rosamma: Kannan's girlfriend.
• Unni Nair as Ambooty, Vidhu's father.
• Arun as Chakkara / Chakkaraparambil Arun: Kannan's best friend.
• Malathi G. Menon as Subadhra, Unknown mother.
• Dhatri as Chinnu: Sahadevan's daughter, Chikku and Chinnan's sister.
• Aadhish Sudhakaran as Chikku: Sahadevan's elder son, Chinnu and Chinnan's brother.
• Vaishnav Menon as Chinnan: Sahadevan's younger son, Chinnu and Chikku's brother.
• Dhvani as Neenu: Meenakshi's best friend.
• Reshmi Anil as Meenkari Susheela
• Vinod Kovoor asDoctor
• Meenakshi Raveendran as Nurse
• Sreelatha Namboothiri as Komalavally: Mohanavally's mother.
• Kochu Preman as Madhavan: Mayavathi's younger brother.
• Anitha Nair as Thankamani: Kamalasanan's breadwinner wife.
• Unknown as Bhavani: Kokila's daughter.
• Unknown as Bharathi: Kokila's daughter.
• Unknown as Shishupalan: Kokila's husband and Arjunan's younger brother-in-law.

• Kaviyoor Ponnamma as Herself, and Krishnan Vakkeel's co-star in a film (Season 1: Ep. 108)
• Vishnu Unnikrishnan as Himself (Season 2: Epi 189)
• Bibin George as Himself (Season 2: Epi 189)
• K. T. S. Padannayil as Mohanavally's Ammavan (Season 1: Ep 276)
• Harisree yousaf as nakulan (season 1 episode 64)
• Promy as Subru
• Nitha Promy as Rukku
• Archana Menon as Adv. Kamala, Mohanavally's friend (Season 1: Episode 306)
• Kavita as Mallika
• Mintu Maria Vincent as Mrunalini
• Sini Prasad as Annamma Chacko, Arjunan's new strict boss, Executive Engineer (Season 2: 313,314)
• Sethu Lakshmi

• Unknown as Pavanan: Arjunan's neighbour.
• Unknown as Shakuntala: Pavavan's wife.