Tetrahydrocolumbamine 2-O-methyltransferase

In enzymology, a tetrahydrocolumbamine 2-O-methyltransferase (EC 2.1.1.89) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine S-adenosyl-L-homocysteine + tetrahydropalmatine
tetrahydrocolumbamine 2-O-methyltransferase
Identifiers
EC number2.1.1.89
CAS number93792-09-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are S-adenosyl methionine and 5,8,13,13a-tetrahydrocolumbamine, whereas its two products are S-adenosylhomocysteine and tetrahydropalmatine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase. This enzyme is also called tetrahydrocolumbamine methyltransferase. This enzyme participates in alkaloid biosynthesis i.

References

    • Beecher CW, Kelleher WJ (1984). "Enzymatic study of the late stages of protoberberine alkaloid biosynthesis". Tetrahedron Lett. 25 (41): 4595–4598. doi:10.1016/S0040-4039(01)91208-0.


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