Testosterone 17b-dehydrogenase (NADP+)
Testosterone 17beta-dehydrogenase (NADP+) (EC 1.1.1.64, 17-ketoreductase, NADP-dependent testosterone-17beta-oxidoreductase, testosterone 17beta-dehydrogenase (NADP)) is an enzyme with systematic name 17beta-hydroxysteroid:NADP+ 17-oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction
- testosterone + NADP+ androstenedione + NADPH + H+
| Testosterone 17beta-dehydrogenase (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.64 | ||||||||
| CAS number | 9028-63-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.
References
- Endahl GL, Kochakian CD, Hamm D (October 1960). "Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine nucleotide-specific 17 beta-hydroxy-(testosterone) dehydrogenase of guinea pig liver". The Journal of Biological Chemistry. 235: 2792–6. PMID 13696735.
- Sweat ML, Samuels LT, Lumry R (July 1950). "Preparation and characterization of the enzyme which converts testosterone to androstenedione". The Journal of Biological Chemistry. 185 (1): 75–84. PMID 15436478.
- Villee CA, Spencer JM (December 1960). "Some properties of the pyridine nucleotide-specific 17 beta-hydroxy steroid dehydrogenases of guinea pig liver". The Journal of Biological Chemistry. 235: 3615–9. PMID 13781425.
External links
- Testosterone+17beta-dehydrogenase+(NADP+) at the US National Library of Medicine Medical Subject Headings (MeSH)
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