Taxoid 7beta-hydroxylase

Taxoid 7beta-hydroxylase (EC 1.14.13.147) is an enzyme with systematic name taxusin,NADPH:oxygen 7-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

taxusin + O2 + NADPH + H+ 7beta-hydroxytaxusin + NADP+ + H2O
Taxoid 7beta-hydroxylase
Identifiers
EC number1.14.13.147
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Taxoid 7beta-hydroxylase requires cytochrome P450.

References

  1. Chau M, Jennewein S, Walker K, Croteau R (May 2004). "Taxol biosynthesis: Molecular cloning and characterization of a cytochrome P450 taxoid 7 beta-hydroxylase". Chemistry & Biology. 11 (5): 663–72. doi:10.1016/j.chembiol.2004.02.025. PMID 15157877.
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