TRNA (guanine9-N1)-methyltransferase
TRNA (guanine9-N1)-methyltransferase (EC 2.1.1.221, Trm10p, tRNA(m1G9/m1A9)-methyltransferase, tRNA(m1G9/m1A9)MTase, tRNA (guanine-N(1)-)-methyltransferase, tRNA m1G9-methyltransferase, tRNA m1G9 MTase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine9-N1)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + guanine9 in tRNA S-adenosyl-L-homocysteine + N1-methylguanine9 in tRNA
| TRNA (guanine9-N1)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.221 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme from Saccharomyces cerevisiae specifically methylates guanine9.
References
- Kempenaers M, Roovers M, Oudjama Y, Tkaczuk KL, Bujnicki JM, Droogmans L (October 2010). "New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA". Nucleic Acids Research. 38 (19): 6533–43. doi:10.1093/nar/gkq451. PMC 2965216. PMID 20525789.
- Jackman JE, Montange RK, Malik HS, Phizicky EM (May 2003). "Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9". RNA. 9 (5): 574–85. doi:10.1261/rna.5070303. PMC 1370423. PMID 12702816.
External links
- TRNA+(guanine9-N1)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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