TRNA (cytidine34-2'-O)-methyltransferase

tRNA (cytidine34-2'-O)-methyltransferase (EC 2.1.1.207, yibK (gene), methyltransferase yibK, TrmL, tRNA methyltransferase L, tRNA (cytidine34/5-carboxymethylaminomethyluridine34-2'-O)-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine34/5-carboxymethylaminomethyluridine34-2'-O)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

(1) S-adenosyl-L-methionine + cytidine34 in tRNA S-adenosyl-L-homocysteine + 2'-O-methylcytidine34 in tRNA
(2) S-adenosyl-L-methionine + 5-carboxymethylaminomethyluridine34 in tRNALeu S-adenosyl-L-homocysteine + 5-carboxymethylaminomethyl-2'-O-methyluridine34 in tRNALeu
tRNA (cytidine34-2'-O)-methyltransferase
Identifiers
EC number2.1.1.207
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme from Escherichia coli catalyses the 2'-O-methylation of cytidine or 5-carboxymethylaminomethyluridine at the wobble position at nucleotide 34 in tRNALeuCmAA and tRNALeucmnm5UmAA.

References

  1. Benítez-Páez A, Villarroya M, Douthwaite S, Gabaldón T, Armengod ME (November 2010). "YibK is the 2'-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNA(Leu) isoacceptors". RNA. 16 (11): 2131–43. doi:10.1261/rna.2245910. PMC 2957053. PMID 20855540.
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