TRNA (cytidine32/uridine32-2'-O)-methyltransferase
TRNA (cytidine32/uridine32-2'-O)-methyltransferase (EC 2.1.1.200, YfhQ, tRNA:Cm32/Um32 methyltransferase, TrMet(Xm32), TrmJ) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine32/uridine32-2'-O)-methyltransferase.[1] This enzyme catalyses the following chemical reaction
- (1) S-adenosyl-L-methionine + cytidine32 in tRNA S-adenosyl-L-homocysteine + 2'-O-methylcytidine32 in tRNA
- (2) S-adenosyl-L-methionine + uridine32 in tRNA S-adenosyl-L-homocysteine + 2'-O-methyluridine32 in tRNA
| TRNA (cytidine32/uridine32-2'-O)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.200 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In Escherichia coli YfhQ is the only methyltransferase responsible for the formation of 2'-O-methylcytidine32 in tRNA.
References
- Purta E, van Vliet F, Tkaczuk KL, Dunin-Horkawicz S, Mori H, Droogmans L, Bujnicki JM (July 2006). "The yfhQ gene of Escherichia coli encodes a tRNA:Cm32/Um32 methyltransferase". BMC Molecular Biology. 7: 23. doi:10.1186/1471-2199-7-23. PMC 1569432. PMID 16848900.
External links
- TRNA+(cytidine32/uridine32-2'-O)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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