TRNA (adenine22-N1)-methyltransferase

TRNA (adenine22-N1)-methyltransferase (EC 2.1.1.217, TrmK, YqfN, Sp1610 (gene), tRNA: m1A22 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (adenine22-N1)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenine22 in tRNA S-adenosyl-L-homocysteine + N1-methyladenine22 in tRNA
TRNA (adenine22-N1)-methyltransferase
Identifiers
EC number2.1.1.217
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme specifically methylates adenine22 in tRNA.

References

  1. Ta HM, Kim KK (March 2010). "Crystal structure of Streptococcus pneumoniae Sp1610, a putative tRNA methyltransferase, in complex with S-adenosyl-L-methionine". Protein Science. 19 (3): 617–24. doi:10.1002/pro.319. PMC 2866285. PMID 20052680.
  2. Roovers M, Kaminska KH, Tkaczuk KL, Gigot D, Droogmans L, Bujnicki JM (June 2008). "The YqfN protein of Bacillus subtilis is the tRNA: m1A22 methyltransferase (TrmK)". Nucleic Acids Research. 36 (10): 3252–62. doi:10.1093/nar/gkn169. PMC 2425500. PMID 18420655.
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