tRNA (adenine-N6-)-methyltransferase
In enzymology, a tRNA (adenine-N6-)-methyltransferase (EC 2.1.1.55) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + tRNA S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine
| tRNA (adenine-N6-)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.55 | ||||||||
| CAS number | 9014-53-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing N6-methyladenine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase. This enzyme is also called S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase.
References
- Mandel LR, Hacker B, Maag TA (1971). "Altered transfer RNA methylase patterns in Marek's disease tumors". Cancer Res. 31 (5): 613–6. PMID 4996578.
- Mittelman A, Hall RH, Yohn DS, Grace JT Jr (1967). "The in vitro soluble RNA methylase activity of SV40-induced hamster tumors". Cancer Res. 27 (8): 1409–14. PMID 4292682.
- Sharma OK (1973). "Differences in the transfer RNA methyltransferases from normal rat liver and Novikoff hepatoma". Biochim. Biophys. Acta. 299 (3): 415–27. doi:10.1016/0005-2787(73)90266-9. PMID 4349332.
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