TRNASer (uridine44-2'-O)-methyltransferase
TRNASer (uridine44-2'-O)-methyltransferase (EC 2.1.1.211, TRM44) is an enzyme with systematic name S-adenosyl-L-methionine:tRNASer (uridine44-2'-O)-methyltransferase.[1] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + uridine44 in tRNASer S-adenosyl-L-homocysteine + 2'-O-methyluridine44 in tRNASer
| TRNASer (uridine44-2'-O)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.211 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The 2'-O-methylation of uridine44 contributes to stability of tRNASer(CGA).
References
- Kotelawala L, Grayhack EJ, Phizicky EM (January 2008). "Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species". RNA. 14 (1): 158–69. doi:10.1261/rna.811008. PMC 2151035. PMID 18025252.
External links
- TRNASer+(uridine44-2'-O)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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