tRNA-uridine aminocarboxypropyltransferase

In enzymology, a tRNA-uridine aminocarboxypropyltransferase (EC 2.5.1.25) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + tRNA uridine 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine
tRNA-uridine aminocarboxypropyltransferase
Identifiers
EC number2.5.1.25
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and tRNA uridine, whereas its two products are 5'-methylthioadenosine and tRNA 3-(3-amino-3-carboxypropyl)-uridine.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase.

References

    • Nishimura S, Taya Y, Kuchino Y, Oashi Z (1974). "Enzymatic synthesis of 3-(3-amino-3-carboxypropyl)uridine in Escherichia coli phenylalanine transfer RNA: transfer of the 3-amino-acid-3-carboxypropyl group from S-adenosylmethionine". Biochem. Biophys. Res. Commun. 57 (3): 702–8. doi:10.1016/0006-291X(74)90603-2. PMID 4597321.


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