TPSD1

Tryptase delta is an enzyme that in humans is encoded by the TPSD1 gene.[3][4]

TPSD1
Identifiers
AliasesTPSD1, MCP7-LIKE, MCP7L1, MMCP-7L, tryptase delta 1
External IDsOMIM: 609272 HomoloGene: 130655 GeneCards: TPSD1
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16p13.3Start1,256,059 bp[1]
End1,259,008 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23430

n/a

Ensembl

ENSG00000095917

n/a

UniProt

Q9BZJ3

n/a

RefSeq (mRNA)

NM_012217

n/a

RefSeq (protein)

NP_036349

n/a

Location (UCSC)Chr 16: 1.26 – 1.26 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. This gene was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein.[4]

References

  1. GRCh38: Ensembl release 89: ENSG00000095917 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Pallaoro M, Fejzo MS, Shayesteh L, Blount JL, Caughey GH (Feb 1999). "Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3". J Biol Chem. 274 (6): 3355–62. doi:10.1074/jbc.274.6.3355. PMID 9920877.
  4. "Entrez Gene: TPSD1 tryptase delta 1".

Further reading


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