TNFSF12-TNFSF13

TNFSF12-TNFSF13
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4HT1
Identifiers
Aliases	TNFSF12-TNFSF13, TWE-PRIL, TNFSF12-TNFSF13 readthrough
External IDs	MGI: 3845075 HomoloGene: 123930 GeneCards: TNFSF12-TNFSF13
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	7,561,601 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	69,696,098 bp[2]
Gene ontology
Molecular function	• cytokine activity; • GO:0001948 protein binding; • tumor necrosis factor receptor binding; • receptor binding;
Cellular component	• integral component of membrane; • membrane; • cell membrane; • integral component of plasma membrane; • extracellular region; • perinuclear region of cytoplasm; • extracellular;
Biological process	• cell differentiation; • positive regulation of endothelial cell proliferation; • positive regulation of protein catabolic process; • extrinsic apoptotic signaling pathway; • tumor necrosis factor-mediated signaling pathway; • positive regulation of angiogenesis; • multicellular organism development; • angiogenesis; • immune response; • apoptotic signaling pathway; • positive regulation of extrinsic apoptotic signaling pathway; • endothelial cell migration; • signal transduction; • apoptotic process; • regulation of receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	407977
	619441
	ENSG00000248871
	ENSMUSG00000018752
	O43508
	n/a
	NM_172089
	NM_001034097; NM_001034098; NM_001159503
	NP_003800
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor (ligand) superfamily, member 12-member 13, also known as TNFSF12-TNFSF13, is a human gene.[5]

This gene belongs to the tumor necrosis factor superfamily (TNFSF). It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of the family member 12 fused to the C-terminal domain of the family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of the family member 13 at the cell surface. It stimulates cycling in T-lymphoma and B-lymphoma cell lines. The mRNA transcript is expressed and translated in primary T cells and monocytes.[5]

References

GRCh38: Ensembl release 89: ENSG00000248871 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000018752 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: TNFSF12-TNFSF13 tumor necrosis factor (ligand) superfamily, member 12-member 13".

Hahne M, Kataoka T, Schröter M, et al. (1998). "APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth". J. Exp. Med. 188 (6): 1185–90. doi:10.1084/jem.188.6.1185. PMC 2212534. PMID 9743536.
Kelly K, Manos E, Jensen G, et al. (2000). "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death". Cancer Res. 60 (4): 1021–7. PMID 10706119.
Wu Y, Bressette D, Carrell JA, et al. (2001). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". J. Biol. Chem. 275 (45): 35478–85. doi:10.1074/jbc.M005224200. PMID 10956646.
Yu G, Boone T, Delaney J, et al. (2001). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity". Nat. Immunol. 1 (3): 252–6. doi:10.1038/79802. PMID 10973284.
López-Fraga M, Fernández R, Albar JP, Hahne M (2002). "Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase". EMBO Rep. 2 (10): 945–51. doi:10.1093/embo-reports/kve198. PMC 1084076. PMID 11571266.
Roschke V, Sosnovtseva S, Ward CD, et al. (2002). "BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases". J. Immunol. 169 (8): 4314–21. doi:10.4049/jimmunol.169.8.4314. PMID 12370363.
Pradet-Balade B, Medema JP, López-Fraga M, et al. (2002). "An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK–APRIL fusion protein". EMBO J. 21 (21): 5711–20. doi:10.1093/emboj/cdf565. PMC 131062. PMID 12411489.
Hendriks J, Planelles L, de Jong-Odding J, et al. (2005). "Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation". Cell Death Differ. 12 (6): 637–48. doi:10.1038/sj.cdd.4401647. PMID 15846369.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000248871 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018752 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TNFSF12-TNFSF13 tumor necrosis factor (ligand) superfamily, member 12-member 13".

TNFSF12-TNFSF13

References

Further reading