Sphingosine N-acyltransferase
In enzymology, a sphingosine N-acyltransferase (EC 2.3.1.24) is an enzyme that catalyzes the chemical reaction
- acyl-CoA + sphingosine CoA + N-acylsphingosine
| sphingosine N-acyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.24 | ||||||||
| CAS number | 37257-09-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are acyl-CoA and sphingosine, whereas its two products are CoA and N-acylsphingosine.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:sphingosine N-acyltransferase. Other names in common use include ceramide synthetase, and sphingosine acyltransferase. This enzyme participates in sphingolipid metabolism.
References
- Sribney M (December 1966). "Enzymatic synthesis of ceramide". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 125 (3): 542–7. doi:10.1016/0005-2760(66)90042-7. PMID 5973195.
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