Serine 3-dehydrogenase

In enzymology, a serine 3-dehydrogenase (EC 1.1.1.276) is an enzyme that catalyzes the chemical reaction

L-serine + NADP+ 2-ammoniomalonate semialdehyde + NADPH + H+
serine 3-dehydrogenase
Identifiers
EC number1.1.1.276
CAS number9038-55-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are L-serine and NADP+, whereas its 3 products are 2-ammoniomalonate semialdehyde, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-serine:NADP+ 3-oxidoreductase.

References

    • Fujisawa H, Nagata S, Chowdhury EK, Matsumoto M, Misono H (2002). "Cloning and sequencing of the serine dehydrogenase gene from Agrobacterium tumefaciens". Biosci. Biotechnol. Biochem. 66 (5): 1137–9. doi:10.1271/bbb.66.1137. PMID 12092831.
    • Chowdhury EK, Higuchi K, Nagata S, Misono H (1997). "A novel NADP(+)-dependent serine dehydrogenase from Agrobacterium tumefaciens". Biosci. Biotechnol. Biochem. 61 (1): 152–7. doi:10.1271/bbb.61.152. PMID 9028042.


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