Saturday Night Live (season 24)

• The Smashing Pumpkins performs "Perfect" and appeared in the Roxbury Guys sketch.
• John Goodman made a cameo appearance as Linda Tripp during the cold open.
• Jonathan Richman and Tommy Larkins, who performed musical interludes in Diaz's film There's Something About Mary, made a cameo appearance after the "What Does That Smell Like" sketch.
• Dan Aykroyd and Steve Martin reprise their roles as The Festrunk Brothers (a.k.a. "The Wild and Crazy Guys") during the Roxbury Guys sketch.
• Jimmy Fallon, Chris Parnell and Horatio Sanz's first episode as cast members (they are not credited as such, however, until the next episode).

• Sheryl Crow performs "My Favorite Mistake" with Wendy Melvoin.
• Shaquille O'Neal appeared in two sketches: "Big Bernard," about an overgrown man who comes home late and receives a spanking from his father (played by Tracy Morgan), and "Morning Latte" as himself.
• Guest appearances by Christine Baranski, Hal Linden and Patti Lupone, who were in the "Wet 'em Down!" sketch

• Elliott Smith performs "Waltz #2".
• Chucky, the possessed doll from Bride of Chucky and related films, made a guest appearance on "Weekend Update", albeit voiced by another person.
• Judge Judy appeared as herself in a sketch in which she is being mocked by Cheri Oteri.
• Writer and future cast member Tina Fey appears during the monologue.

• Alanis Morissette performs "Thank U" and "Baba".
• New York Yankees players David Cone, Chili Davis, Graeme Lloyd, Tino Martinez and David Wells appeared in the opening monologue.

• Eagle-Eye Cherry performs "Save Tonight".
• Brad Pitt appeared in the cold opening where David Spade visits his therapist (played by Pitt) about his overwhelming fame.
• Former cast member Chris Rock cameoed in a Mango sketch as an admirer of a new dancer named Kiwi (played by David Spade).

• Jewel performs "Hands" and "Down So Long".
• John Goodman made a cameo in a Suel Forrester Sketch.

• Beastie Boys performs "Three MC's and One DJ" and "Sabotage".
• Beastie Boy Adam Horovitz made a cameo appearance during the Spartan Cheerleaders sketch as Jennifer Love Hewitt's character's boyfriend.
• Hewitt's co-star in the I Know What You Did Last Summer films, Muse Watson, made a cameo during the monologue as his character Ben Willis.
• John Goodman made a cameo in the cold open as Linda Tripp.

• Lauryn Hill performs "Doo Wop (That Thing)" and "Ex-Factor".
• Vince Vaughn appeared as a nervous bridegroom seeking advice from his buddies, Will Ferrell and Jimmy Fallon, in "The Joys of Marriage".

Luciano Pavarotti and Vanessa Williams performs "Adeste Fideles".

• Vanessa Williams also appeared as a 'Kwanzette' during Weekend Update while Tim Meadows sings a song about Kwanzaa with Janice Pendarvis.
• John Goodman had a cameo appearance during Baldwin's monologue and in the "Bill Brasky" sketch featuring Goodman, Will Ferrell, and Alec Baldwin as drunken businessmen.
• Jimmy Fallon appears as the "ghost of hosts' future" during Alec Baldwin's monologue, where he is supposed to be a big star in 2011, have is own show and host Saturday Night Live on the December 12 of 2011 episode. These predictions will become true as he will indeed be hosting on the tenth episode of season 37, which aired on December 18 of 2011, and have his own show, Late Night with Jimmy Fallon, in 2011.

• Beck performs "Nobody's Fault but My Own" and "Tropicalia". He also appeared in the Behind the Music parody sketch.
• Titanic director James Cameron had a pre-recorded cameo in a sketch parodying his film.
• Debbie Matenopoulos appeared as herself in a parody of The View.

• Everlast performs "What It's Like".
• Colin Quinn's last pre-Weekend Update monologue.
• Darrell Hammond imitated an absent Don Pardo as announcer, particularly in a two-part running gag where 'Don Pardo' (Darrell Hammond) tries to seduce Van Der Beek.

• Barenaked Ladies performs "It's All Been Done".
• Ben Affleck cameoed in Paltrow's opening monologue.
• Writer and future cast member Tina Fey appeared during the monologue.

• Busta Rhymes and The Roots performs "Gimme Some More" and "Tear da Roof Off".
• John Goodman cameos as Linda Tripp during the cold open.
• Former SNL writer/featured player Tom Davis appeared in the monologue.
• George Plimpton appears after the "Shut Up and Enjoy the Ozzy" sketch.

• Lucinda Williams performs "Can't Let Go" and "2 Kool 2 Be 4-gotten".
• Former castmember (and co-star of Caddyshack) Chevy Chase appeared in the "Quotable Caddyshack" sketch to re-enact his one scene with Bill Murray.
• Stephanie Seymour cameoed in the "Ladies Man" cold open.
• Rebroadcasts the "Swill" commercial parody from the 1976 season, starring Bill Murray.

• The Corrs performs "What Can I Do?" and "So Young".
• Romano's Everybody Loves Raymond co-stars, Peter Boyle and Doris Roberts, made cameo appearances during the monologue, in which Boyle discussed his time as host in the 1970s and Roberts discussed her role in My Giant.

• Garbage performs "Special" and "When I Grow Up".
• Edward Norton cameoed in a VH1 commercial parody as Daryl Dragon.

• Tom Petty & The Heartbreakers performs "Swingin'" and "Room at the Top".
• Writer and future cast member Tina Fey appears as a fake audience member interrupting the host during the monologue.

• Ricky Martin performs "Livin' La Vida Loca".
• Monica Lewinsky made a special appearance in the cold open where Bill Clinton (played by Darrell Hammond) imagines life after his Presidency, and in a sketch with Tim Meadows' Ladies Man character.
• John Goodman makes a voice-only guest appearance as Linda Tripp in the "Ladies Man" sketch.

• Backstreet Boys performs "I Want It That Way" and "All I Have to Give".
• David Boreanaz, Howie Dorough (from the Backstreet Boys) and Seth Green cameoed in the recurring sketch, "Tiger Beat's Ultra Super Duper Dreamy Love Show".