SYN3

SYN3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2P0A
Identifiers
Aliases	SYN3, synapsin III
External IDs	OMIM: 602705 MGI: 1351334 HomoloGene: 68320 GeneCards: SYN3
Gene location (Human)
Chr.	Chromosome 22 (human)[1]
End	33,058,381 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	86,498,896 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• nucleotide binding; • ATP binding;
Cellular component	• cell junction; • synapse; • synaptic vesicle membrane; • membrane; • cytoplasmic vesicle; • synaptic vesicle; • postsynaptic density; • glutamatergic synapse;
Biological process	• regulation of synaptic transmission, GABAergic; • neurotransmitter secretion; • synaptic vesicle clustering; • synaptic vesicle cycle;
	Sources:Amigo / QuickGO
Orthologs
	8224
	27204
	ENSG00000185666
	ENSMUSG00000059602
	O14994
	Q8JZP2
NM_001135774; NM_003490; NM_133632; NM_133633; NM_001369907;
	NM_001369908; NM_001369909; NM_001369910
	NM_001164495; NM_013722
NP_001129246; NP_003481; NP_598344; NP_001356836; NP_001356837;
	NP_001356838; NP_001356839
	NP_001157967; NP_038750
	Wikidata
View/Edit Human	View/Edit Mouse

Synapsin-3 is a protein that in humans is encoded by the SYN3 gene.[5][6]

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in six transcript variants; however, only two variants have been fully described.[6]

References

GRCh38: Ensembl release 89: ENSG00000185666 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000059602 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kao HT, Porton B, Czernik AJ, Feng J, Yiu G, Haring M, Benfenati F, Greengard P (May 1998). "A third member of the synapsin gene family". Proc Natl Acad Sci U S A. 95 (8): 4667–72. doi:10.1073/pnas.95.8.4667. PMC 22548. PMID 9539796.
"Entrez Gene: SYN3 synapsin III".

Hosaka M, Südhof TC (1999). "Homo- and heterodimerization of synapsins". J. Biol. Chem. 274 (24): 16747–53. doi:10.1074/jbc.274.24.16747. PMID 10358015.
Kao HT, Porton B, Hilfiker S, et al. (2000). "Molecular evolution of the synapsin gene family". J. Exp. Zool. 285 (4): 360–77. doi:10.1002/(SICI)1097-010X(19991215)285:4<360::AID-JEZ4>3.0.CO;2-3. PMID 10578110.
Porton B, Kao HT, Greengard P (1999). "Characterization of transcripts from the synapsin III gene locus". J. Neurochem. 73 (6): 2266–71. doi:10.1046/j.1471-4159.1999.0732266.x. PMID 10582583.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Tsai MT, Hung CC, Tsai CY, et al. (2002). "Mutation analysis of synapsin III gene in schizophrenia". Am. J. Med. Genet. 114 (1): 79–83. doi:10.1002/ajmg.10116. PMID 11840510.
Jaffrey SR, Benfenati F, Snowman AM, et al. (2002). "Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 3199–204. doi:10.1073/pnas.261705799. PMC 122496. PMID 11867766.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Porton B, Ferreira A, DeLisi LE, Kao HT (2004). "A rare polymorphism affects a mitogen-activated protein kinase site in synapsin III: possible relationship to schizophrenia". Biol. Psychiatry. 55 (2): 118–25. doi:10.1016/j.biopsych.2003.07.002. PMID 14732590.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lachman HM, Stopkova P, Rafael MA, Saito T (2005). "Association of schizophrenia in African Americans to polymorphism in synapsin III gene". Psychiatr. Genet. 15 (2): 127–32. doi:10.1097/00041444-200506000-00009. PMID 15900227.
Lachman HM, Stopkova P, Papolos DF, et al. (2006). "Analysis of synapsin III-196 promoter mutation in schizophrenia and bipolar disorder". Neuropsychobiology. 53 (2): 57–62. doi:10.1159/000091720. PMID 16511335.
Makkar R, Gomez L, Wigg KG, et al. (2007). "The gene for synapsin III and attention-deficit hyperactivity disorder". Psychiatr. Genet. 17 (2): 109–12. doi:10.1097/YPG.0b013e328012a0c6. PMID 17413450.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185666 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059602 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9539796-5] Kao HT, Porton B, Czernik AJ, Feng J, Yiu G, Haring M, Benfenati F, Greengard P (May 1998). "A third member of the synapsin gene family". Proc Natl Acad Sci U S A. 95 (8): 4667–72. doi:10.1073/pnas.95.8.4667. PMC 22548. PMID 9539796.

[entrez-6] "Entrez Gene: SYN3 synapsin III".

Protein: nerve tissue protein
Synuclein	Alpha-synuclein Beta-synuclein Gamma-synuclein
Other	Agrin Chimerin Granin Chromogranin A B FMR1 Gap-43 protein GLUT3 Myelin Brain natriuretic peptide Nerve growth factor SCG5 Neurogranin Neuronal calcium sensor Neuropeptide Olfactory marker protein S100 protein Calgranulin Synapsin 1 2 3 Synaptophysin Tubulin GPM6A

SYN3

References

Further reading