STK35L1

STK35L1 is a protein that in humans is encoded by the STK35 (serine/threonine kinase 35) gene.[5] It is a member of the NKF4 (New Kinase Family 4) Ser/Thr kinases (STK) family and classified in group "Other" in the human kinome. Previously, STK35L1 was named as Clik1 (CLP36 Interacting Kinase 1) based on a study that showed an association of STK35 with CLP36 after overexpression of both proteins in osteosarcoma cells.[6][7] Clik1 gene described by Vallenius et al. code for a protein of 501 amino acids. Later, Goyal et al. found that coding sequence of the STK35 gene is incomplete. The newly identified sequence of the STK35 gene codes for a protein of 534 amino acids with a N-terminal elongation of 133 amino acids. It has been designated as STK35L1.

STK35
Identifiers
AliasesSTK35, serine/threonine kinase 35, CLIK1, STK35L1, Serine/threonine kinase 35
External IDsOMIM: 609370 MGI: 1914583 HomoloGene: 15441 GeneCards: STK35
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20p13Start2,101,827 bp[1]
End2,177,038 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

140901

67333

Ensembl

ENSG00000125834

ENSMUSG00000037885

UniProt

Q8TDR2

Q80ZW0

RefSeq (mRNA)

NM_080836

NM_001038635
NM_183262

RefSeq (protein)

NP_543026

NP_001033724
NP_899085

Location (UCSC)Chr 20: 2.1 – 2.18 MbChr 2: 129.8 – 129.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Functions

STK35L1 is predominantly found in the nucleus and the nucleolus. Nuclear actin was identified as a novel binding partner of STK35L1.[8] However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. STK35L1 regulates the expression of CDKN2A and inhibiting G1- to S-phase transition. Depletion of STK35L1 by siRNA impaired endothelial cell migration. STK35L1 may act as a central kinase linking the cell cycle and migration of endothelial cells.

References
  1. GRCh38: Ensembl release 89: ENSG00000125834 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037885 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Serine/threonine kinase 35". Retrieved 2012-02-18.
  6. Vallenius T, Mäkelä TP (May 2002). "Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein". Journal of Cell Science. 115 (Pt 10): 2067–73. PMID 11973348.
  7. Goyal P, Behring A, Kumar A, Siess W (2009-09-16). "Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates". PLoS One. 4 (9): e6981. doi:10.1371/journal.pone.0006981. PMC 2737284. PMID 19756140.
  8. Goyal P, Behring A, Kumar A, Siess W (2011-01-20). "STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells". PLoS One. 6 (1): e16249. doi:10.1371/journal.pone.0016249. PMC 3024402. PMID 21283756.

Further reading


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