Premnaspirodiene oxygenase
Premnaspirodiene oxygenase (EC 1.14.13.121, HPO, Hyoscymus muticus premnaspirodiene oxygenase) is an enzyme with systematic name (-)-vetispiradiene,NADPH:oxygen 2alpha-oxidoreductase.[1] This enzyme catalyses the following chemical reaction
- (-)-vetispiradiene + 2 NADPH + 2 H+ + 2 O2 solavetivone + 2 NADP+ + 3 H2O (overall reaction)
- (1a) (-)-vetispiradiene + NADPH + H+ + O2 solavetivol + NADP+ + H2O
- (1b) solavetivol + NADPH + H+ + O2 solavetivone + NADP+ + 2 H2O
| Premnaspirodiene oxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.121 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
References
- Takahashi S, Yeo YS, Zhao Y, O'Maille PE, Greenhagen BT, Noel JP, Coates RM, Chappell J (October 2007). "Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates". The Journal of Biological Chemistry. 282 (43): 31744–54. doi:10.1074/jbc.M703378200. PMC 2695360. PMID 17715131.
External links
- Premnaspirodiene+oxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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