Plasmalogen synthase

In enzymology, a plasmalogen synthase (EC 2.3.1.25) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine CoA + plasmenylcholine
plasmalogen synthase
Identifiers
EC number2.3.1.25
CAS number37257-10-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are acyl-CoA and 1-O-alk-1-enyl-glycero-3-phosphocholine, whereas its two products are CoA and plasmenylcholine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-O-alk-1-enyl-glycero-3-phosphocholine 2-O-acyltransferase. Other names in common use include lysoplasmenylcholine acyltransferase, O-1-alkenylglycero-3-phosphorylcholine acyltransferase, and 1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase. This enzyme participates in ether lipid metabolism.

References

    • Waku K, Lands WE (1968). "Acyl coenzyme A:1-alkenyl-glycero-3-phosphorylcholine acyltransferase action in plasmalogen biosynthesis". J. Biol. Chem. 243 (10): 2654–9. PMID 5689955.


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