Plasma kallikrein
Plasma kallikrein (EC 3.4.21.34, serum kallikrein, kininogenin, kallikrein I, kallikrein II, kininogenase, kallikrein, callicrein, glumorin, padreatin, padutin, kallidinogenase, bradykininogenase, panceatic kallikrein, onokrein P, dilminal D, depot-Padutin, urokallikrein, urinary kallikrein) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Selective cleavage of some Arg- and Lys- bonds, including Lys-Arg and Arg-Ser in (human) kininogen to release bradykinin
| Plasma kallikrein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.21.34 | ||||||||
| CAS number | 410538-33-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is formed from plasma prokallikrein (Fletcher factor) by factor XIIa.
See also
References
- Heimark RL, Davie EW (1981). "Bovine and human plasma prekallikrein". Methods in Enzymology. 80 Pt C: 157–72. doi:10.1016/s0076-6879(81)80016-x. PMID 6918767.
- McRae BJ, Kurachi K, Heimark RL, Fujikawa K, Davie EW, Powers JC (December 1981). "Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates". Biochemistry. 20 (25): 7196–206. doi:10.1021/bi00528a022. PMID 6976185.
- Silverberg M, Kaplan AP (1988). "Prekallikrein". Methods in Enzymology. 163: 85–95. doi:10.1016/0076-6879(88)63010-2. ISBN 9780121820640. PMID 3237096.
- Seidah NG, Ladenheim R, Mbikay M, Hamelin J, Lutfalla G, Rougeon F, Lazure C, Chrétien M (October 1989). "The cDNA structure of rat plasma kallikrein". DNA. 8 (8): 563–74. doi:10.1089/dna.1989.8.563. PMID 2598771.
- Tsuda Y, Teno N, Okada Y, Wanaka K, Bohgaki M, Hijikata-Okunomiya A, Okamoto U, Naito T, Okamoto S (November 1989). "Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein". Chemical & Pharmaceutical Bulletin. 37 (11): 3108–11. doi:10.1248/cpb.37.3108. PMID 2534361.
External links
- Plasma+kallikrein at the US National Library of Medicine Medical Subject Headings (MeSH)
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