Phosphatidylcholine—dolichol O-acyltransferase

In enzymology, a phosphatidylcholine---dolichol O-acyltransferase (EC 2.3.1.83) is an enzyme that catalyzes the chemical reaction

3-sn-phosphatidylcholine + dolichol 1-acyl-sn-glycero-3-phosphocholine + acyldolichol
phosphatidylcholine-dolichol O-acyltransferase
Identifiers
EC number2.3.1.83
CAS number9012-30-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are 3-sn-phosphatidylcholine and dolichol, whereas its two products are 1-acyl-sn-glycero-3-phosphocholine and acyldolichol.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 3-sn-phosphatidylcholine:dolichol O-acyltransferase.

References

    • Keenan RW, Kruczek ME (1976). "The esterification of dolichol by rat liver microsomes". Biochemistry. 15 (7): 1586–91. doi:10.1021/bi00652a032. PMID 4095.
    • Radominska-Pyrek A, Chojnacki T, Zulczyk W (1979). "Acyl esters of polyprenols: specificity of microsomal transacylase for polyprenols of different chain length and saturation". Acta Biochim. Pol. 26 (1–2): 125–34. PMID 506613.


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