Phenylacetyl-CoA 1,2-epoxidase

Phenylacetyl-CoA 1,2-epoxidase (EC 1.14.13.149, ring 1,2-phenylacetyl-CoA epoxidase, phenylacetyl-CoA monooxygenase, PaaAC, PaaABC(D)E) is an enzyme with systematic name phenylacetyl-CoA:oxygen oxidoreductase (1,2-epoxidizing).[1][2][3] This enzyme catalyses the following chemical reaction

phenylacetyl-CoA + NADPH + H+ + O2 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP+ + H2O
Phenylacetyl-CoA 1,2-epoxidase
Identifiers
EC number1.14.13.149
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Phenylacetyl-CoA 1,2-epoxidase participates in catabolism of phenylacetate in Escherichia coli and Pseudomonas putida.

References

  1. Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G (August 2010). "Bacterial phenylalanine and phenylacetate catabolic pathway revealed". Proceedings of the National Academy of Sciences of the United States of America. 107 (32): 14390–5. doi:10.1073/pnas.1005399107. PMC 2922514. PMID 20660314.
  2. Grishin AM, Ajamian E, Zhang L, Cygler M (September 2010). "Crystallization and preliminary X-ray analysis of PaaAC, the main component of the hydroxylase of the Escherichia coli phenylacetyl-coenzyme A oxygenase complex". Acta Crystallographica Section F. 66 (Pt 9): 1045–9. doi:10.1107/S174430911002748X. PMC 2935223. PMID 20823522.
  3. Grishin AM, Ajamian E, Tao L, Zhang L, Menard R, Cygler M (March 2011). "Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex". The Journal of Biological Chemistry. 286 (12): 10735–43. doi:10.1074/jbc.M110.194423. PMC 3060524. PMID 21247899.
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