Pentalenolactone F synthase
Pentalenolactone F synthase (EC 1.14.11.36, PEND (gene), PNTD (gene), PTLD (gene)) is an enzyme with systematic name pentalenolactone-D,2-oxoglutarate:oxygen oxidoreductase.[1] This enzyme catalyses the following chemical reaction
- pentalenolactone D + 2 2-oxoglutarate + 2 O2 pentalenolactone F + 2 succinate + 2 CO2 + H2O (overall reaction)
- (1a) pentalenolactone D + 2-oxoglutarate + O2 pentalenolactone E + succinate + CO2 + H2O
- (1b) pentalenolactone E + 2-oxoglutarate + O2 pentalenolactone F + succinate + CO2
| Pentalenolactone F synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.11.36 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Pentalenolactone F synthase contains Fe(II), and ascorbate is needed for its action.
References
- Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE (March 2011). "Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone". Biochemistry. 50 (10): 1739–54. doi:10.1021/bi1019786. PMC 3051010. PMID 21250661.
External links
- Pentalenolactone+F+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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