PTP4A3

Protein tyrosine phosphatase type IVA 3 is an enzyme that in humans is encoded by the PTP4A3 gene.[5]

PTP4A3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTP4A3, PRL-3, PRL-R, PRL3, protein tyrosine phosphatase type IVA, member 3, protein tyrosine phosphatase 4A3
External IDsOMIM: 606449 MGI: 1277098 HomoloGene: 22500 GeneCards: PTP4A3
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q24.3Start141,391,995 bp[1]
End141,432,454 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11156

19245

Ensembl

ENSG00000184489
ENSG00000275575

ENSMUSG00000059895

UniProt

O75365

Q9D658

RefSeq (mRNA)

NM_007079
NM_032611

NM_001166388
NM_001166389
NM_001166390
NM_008975
NM_001357591

RefSeq (protein)

NP_009010
NP_116000

NP_001159860
NP_001159861
NP_001159862
NP_033001
NP_001344520

Location (UCSC)Chr 8: 141.39 – 141.43 MbChr 15: 73.72 – 73.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.[5]

References

  1. ENSG00000275575 GRCh38: Ensembl release 89: ENSG00000184489, ENSG00000275575 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000059895 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: PTP4A3 protein tyrosine phosphatase type IVA, member 3".

Further reading

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