PDSS1

Decaprenyl-diphosphate synthase subunit 1 is an enzyme that in humans is encoded by the PDSS1 gene.[5][6]

PDSS1
Identifiers
AliasesPDSS1, COQ1, COQ10D2, DPS, SPS, TPRT, TPT, TPT 1, hDPS1, prenyl (decaprenyl) diphosphate synthase, subunit 1, decaprenyl diphosphate synthase subunit 1, COQ1A
External IDsOMIM: 607429 MGI: 1889278 HomoloGene: 5353 GeneCards: PDSS1
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10p12.1Start26,697,701 bp[1]
End26,746,798 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23590

56075

Ensembl

ENSG00000148459

ENSMUSG00000026784

UniProt

Q5T2R2

Q33DR2

RefSeq (mRNA)

NM_014317
NM_001321978
NM_001321979

NM_019501
NM_001355467

RefSeq (protein)

NP_001308907
NP_001308908
NP_055132

NP_062374
NP_001342396

Location (UCSC)Chr 10: 26.7 – 26.75 MbChr 2: 22.9 – 22.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000148459 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026784 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Rotig A, Appelkvist EL, Geromel V, Chretien D, Kadhom N, Edery P, Lebideau M, Dallner G, Munnich A, Ernster L, Rustin P (Sep 2000). "Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency". Lancet. 356 (9227): 391–395. doi:10.1016/S0140-6736(00)02531-9. PMID 10972372.
  6. "Entrez Gene: PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.