PCP4

PCP4
Identifiers
Aliases	PCP4, PEP-19, Purkinje cell protein 4
External IDs	OMIM: 601629 MGI: 97509 HomoloGene: 4519 GeneCards: PCP4
Gene location (Human)
Chr.	Chromosome 21 (human)[1]
End	39,929,397 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	96,525,793 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • calcium ion binding; • calmodulin binding;
Cellular component	• cytosol; • cell nucleus; • protein complex; • macromolecular complex;
Biological process	• positive regulation of neuron differentiation; • calmodulin dependent kinase signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5121
	18546
	ENSG00000183036
	ENSMUSG00000090223
	P48539
	P63054
	NM_006198
	NM_008791
	NP_006189
	NP_032817
	Wikidata
View/Edit Human	View/Edit Mouse

Purkinje cell protein 4 is a protein that in humans is encoded by the PCP4 gene.[5][6][7] Also known as PEP-19, PCP4 is a 7.6 kDa protein with an IQ-motif that binds to calmodulin (CaM).[8] PCP4 is abundant in Purkinje cells of the cerebellum, and plays an important role in synaptic plasticity.[8][9]

Function

PCP4 knockout mice have been reported to exhibit impaired locomotor learning and markedly altered synaptic plasticity in cerebellar Purkinje neurons.[8] PCP4 accelerates both the association and dissociation of calcium (Ca²⁺) with calmodulin (CaM), which is postulated to influence the activity of CaM-dependent enzymes, especially CaM kinase II (CaMK-II).[8][10][11]

References

GRCh38: Ensembl release 89: ENSG00000183036 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000090223 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Chen H, Bouras C, Antonarakis SE (Jan 1997). "Cloning of the cDNA for a human homolog of the rat PEP-19 gene and mapping to chromosome 21q22.2-q22.3". Hum Genet. 98 (6): 672–7. doi:10.1007/s004390050282. PMID 8931698.
Cabin DE, Gardiner K, Reeves RH (Dec 1996). "Molecular genetic characterization and comparative mapping of the human PCP4 gene". Somat Cell Mol Genet. 22 (3): 167–75. doi:10.1007/BF02369907. PMID 8914602.
"Entrez Gene: PCP4 Purkinje cell protein 4".
Wei P, Blundon JA, Rong Y, Zakharenko SS, Morgan JI (2011). "Impaired locomotor learning and altered cerebellar synaptic plasticity in pep-19/PCP4-null mice". Mol. Cell. Biol. 31 (14): 2838–44. doi:10.1128/MCB.05208-11. PMC 3133400. PMID 21576365.
Sangameswaran L, Hempstead J, Morgan JI (1989). "Molecular cloning of a neuron-specific transcript and its regulation during normal and aberrant cerebellar development". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5651–5. doi:10.1073/pnas.86.14.5651. PMC 297682. PMID 2748608.
Putkey JA, Kleerekoper Q, Gaertner TR, Waxham MN (2004). "A new role for IQ motif proteins in regulating calmodulin function". J. Biol. Chem. 278 (50): 49667–70. doi:10.1074/jbc.C300372200. PMID 14551202.
Kleerekoper QK, Putkey JA (2009). "PEP-19, an intrinsically disordered regulator of calmodulin signaling". J. Biol. Chem. 284 (12): 7455–64. doi:10.1074/jbc.M808067200. PMC 2658041. PMID 19106096.

Hubert RS, Korenberg JR (1997). "PCP4 maps between D21S345 and P31P10SP6 on chromosome 21q22.2→q22.3". Cytogenet. Cell Genet. 78 (1): 44–5. doi:10.1159/000134623. PMID 9345904.
Utal AK, Stopka AL, Roy M, Coleman PD (1998). "PEP-19 immunohistochemistry defines the basal ganglia and associated structures in the adult human brain, and is dramatically reduced in Huntington's disease". Neuroscience. 86 (4): 1055–63. doi:10.1016/S0306-4522(98)00130-4. PMID 9697113.
Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem P, Lehrach H, Yaspo ML, Janitz M (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183036 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000090223 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8931698-5] Chen H, Bouras C, Antonarakis SE (Jan 1997). "Cloning of the cDNA for a human homolog of the rat PEP-19 gene and mapping to chromosome 21q22.2-q22.3". Hum Genet. 98 (6): 672–7. doi:10.1007/s004390050282. PMID 8931698.

[pmid8914602-6] Cabin DE, Gardiner K, Reeves RH (Dec 1996). "Molecular genetic characterization and comparative mapping of the human PCP4 gene". Somat Cell Mol Genet. 22 (3): 167–75. doi:10.1007/BF02369907. PMID 8914602.

[entrez-7] "Entrez Gene: PCP4 Purkinje cell protein 4".

[Wei_et_al-8] Wei P, Blundon JA, Rong Y, Zakharenko SS, Morgan JI (2011). "Impaired locomotor learning and altered cerebellar synaptic plasticity in pep-19/PCP4-null mice". Mol. Cell. Biol. 31 (14): 2838–44. doi:10.1128/MCB.05208-11. PMC 3133400. PMID 21576365.

[Sangameswaran_et_al-9] Sangameswaran L, Hempstead J, Morgan JI (1989). "Molecular cloning of a neuron-specific transcript and its regulation during normal and aberrant cerebellar development". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5651–5. doi:10.1073/pnas.86.14.5651. PMC 297682. PMID 2748608.

[Putkey_et_al-10] Putkey JA, Kleerekoper Q, Gaertner TR, Waxham MN (2004). "A new role for IQ motif proteins in regulating calmodulin function". J. Biol. Chem. 278 (50): 49667–70. doi:10.1074/jbc.C300372200. PMID 14551202.

[Kleerekoper_&_Putkey-11] Kleerekoper QK, Putkey JA (2009). "PEP-19, an intrinsically disordered regulator of calmodulin signaling". J. Biol. Chem. 284 (12): 7455–64. doi:10.1074/jbc.M808067200. PMC 2658041. PMID 19106096.

PCP4

Function

References

Further reading