Non-specific polyamine oxidase

Non-specific polyamine oxidase (EC 1.5.3.17, polyamine oxidase, Fms1, AtPAO3) is an enzyme with systematic name polyamine:oxygen oxidoreductase (3-aminopropanal or 3-acetamidopropanal-forming).[1][2][3] This enzyme catalyses the following chemical reaction

(1) spermine + O2 + H2O spermidine + 3-aminopropanal + H2O2
(2) spermidine + O2 + H2O putrescine + 3-aminopropanal + H2O2
(3) N1-acetylspermine + O2 + H2O spermidine + 3-acetamidopropanal + H2O2
(4) N1-acetylspermidine + O2 + H2O putrescine + 3-acetamidopropanal + H2O2
Non-specific polyamine oxidase
Identifiers
EC number1.5.3.17
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is flavoprotein (FAD).

References

  1. Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA (August 2008). "Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis". Plant Physiology. 147 (4): 1845–57. doi:10.1104/pp.108.123802. PMC 2492618. PMID 18583528.
  2. Müller S, Walter RD (April 1992). "Purification and characterization of polyamine oxidase from Ascaris suum". The Biochemical Journal. 283 ( Pt 1): 75–80. PMC 1130995. PMID 1567380.
  3. Landry J, Sternglanz R (April 2003). "Yeast Fms1 is a FAD-utilizing polyamine oxidase". Biochemical and Biophysical Research Communications. 303 (3): 771–6. doi:10.1016/s0006-291x(03)00416-9. PMID 12670477.
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