NSP2 (rotavirus)

NSP2, is a rotavirus nonstructural RNA-binding protein that accumulates in cytoplasmic inclusions (viroplasms) and is required for genome replication.[1] NSP2 is closely associated in vivo with the viral replicase.[2] The non-structural protein NSP5 plays a role in the structure of viroplasms mediated by its interaction with NSP2.[3]

NSP2 (rotavirus)
NSP2 octamer, human rotavirus, PDB: 2gu0.
Identifiers
SymbolRota_NS35
PfamPF02509
InterProIPR003668
CATH2gu0
SCOPe2r7j / SUPFAM
Protein folds into two domains.

References

  1. Kattoura MD, Chen X, Patton JT (August 1994). "The rotavirus RNA-binding protein NS35 (NSP2) forms 10S multimers and interacts with the viral RNA polymerase". Virology. 202 (2): 803–813. doi:10.1006/viro.1994.1402. PMID 8030243.
  2. Aponte C, Poncet D, Cohen J (February 1996). "Recovery and characterization of a replicase complex in rotavirus-infected cells by using a monoclonal antibody against NSP2". Journal of Virology. 70 (2): 985–91. PMC 189903. PMID 8551639.
  3. Fabbretti E, Afrikanova I, Vascotto F, Burrone OR (February 1999). "Two non-structural rotavirus proteins, NSP2 and NSP5, form viroplasm-like structures in vivo". The Journal of General Virology. 80 (2): 333–9. doi:10.1099/0022-1317-80-2-333. PMID 10073692.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.