NLRC3

NLRC3
Identifiers
Aliases	NLRC3, CLR16.2, NOD3, NLR family, CARD domain containing 3, NLR family CARD domain containing 3
External IDs	OMIM: 615648 MGI: 2444070 HomoloGene: 18720 GeneCards: NLRC3
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	3,577,403 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	3,976,632 bp[2]
Gene ontology
Molecular function	• nucleotide binding; • ATP binding; • GO:0001948 protein binding; • phosphatidylinositol 3-kinase regulatory subunit binding; • molecular function;
Cellular component	• cytoplasm; • microtubule organizing center; • cytosol; • perinuclear region of cytoplasm;
Biological process	• negative regulation of interleukin-6 production; • negative regulation of tumor necrosis factor production; • I-kappaB kinase/NF-kappaB signaling; • negative regulation of NF-kappaB transcription factor activity; • T cell activation; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • negative regulation of phosphatidylinositol 3-kinase signaling; • negative regulation of interferon-alpha production; • negative regulation of interferon-beta production; • negative regulation of innate immune response; • negative regulation of fibroblast proliferation; • negative regulation of epithelial cell proliferation; • negative regulation of inflammatory response; • negative regulation of cytokine production involved in inflammatory response; • negative regulation of NLRP3 inflammasome complex assembly; • negative regulation of NIK/NF-kappaB signaling; • intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	197358
	268857
	ENSG00000167984
	ENSMUSG00000049871
	Q7RTR2
	Q5DU56
	NM_178844
	NM_001081280; NM_175547
	NP_849172
	NP_001074749; NP_780756
	Wikidata
View/Edit Human	View/Edit Mouse

NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system.[5] It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 (NOD3) and CLR16.2. NLRC3 inhibits the activity of T cells.[6] NLRC3 also inhibits the mTOR signalling pathway to block cellular proliferation.[7]

References

GRCh38: Ensembl release 89: ENSG00000167984 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000049871 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ting JP, Lovering RC, Alnemri ES, et al. (March 2008). "The NLR gene family: a standard nomenclature". Immunity. 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC 2630772. PMID 18341998.
Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (May 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.
Karki, Rajendra; Man, Si Ming; Malireddi, R. K. Subbarao; Kesavardhana, Sannula; Zhu, Qifan; Burton, Amanda R.; Sharma, Bhesh Raj; Qi, Xiaopeng; Pelletier, Stephane; Vogel, Peter; Rosenstiel, Philip (December 2016). "NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer". Nature. 540 (7634): 583–587. doi:10.1038/nature20597. ISSN 1476-4687. PMC 5468516. PMID 27951586.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167984 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049871 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid18341998-5] Ting JP, Lovering RC, Alnemri ES, et al. (March 2008). "The NLR gene family: a standard nomenclature". Immunity. 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC 2630772. PMID 18341998.

[pmid15705585-6] Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (May 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.

[7] Karki, Rajendra; Man, Si Ming; Malireddi, R. K. Subbarao; Kesavardhana, Sannula; Zhu, Qifan; Burton, Amanda R.; Sharma, Bhesh Raj; Qi, Xiaopeng; Pelletier, Stephane; Vogel, Peter; Rosenstiel, Philip (December 2016). "NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer". Nature. 540 (7634): 583–587. doi:10.1038/nature20597. ISSN 1476-4687. PMC 5468516. PMID 27951586.

NOD-like receptor family
CARD domain containing	NOD1/NLRC1 NOD2/NLRC2 NLRC3 NLRC4 NLRC5
Pyrin domain containing	NLRP1 NLRP2 NLRP3 NLRP4 NLRP5 NLRP6 NLRP7 NLRP8 NLRP9 NLRP10 NLRP11 NLRP12 NLRP13 NLRP14
Apoptosis inhibitory protein	NAIP
Family member X1	NLRX1