NADP-retinol dehydrogenase

NADP-retinol dehydrogenase (EC 1.1.1.300, all-trans retinal reductase, all-trans-retinol dehydrogenase, NADP(H)-dependent retinol dehydrogenase/reductase, RDH11, RDH12, RDH13, RDH14, retinol dehydrogenase 12, retinol dehydrogenase 14, retinol dehydrogenase (NADP+), RalR1, PSDR1) is an enzyme with systematic name retinol:NADP+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

retinol + NADP+ retinal + NADPH + H+
NADP-retinol dehydrogenase
Identifiers
EC number1.1.1.300
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme has greater catalytic efficiency in the reductive direction.

References
  1. Belyaeva OV, Korkina OV, Stetsenko AV, Kim T, Nelson PS, Kedishvili NY (May 2005). "Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids". Biochemistry. 44 (18): 7035–47. doi:10.1021/bi050226k. PMC 2679700. PMID 15865448.
  2. Belyaeva OV, Korkina OV, Stetsenko AV, Kedishvili NY (January 2008). "Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity". The FEBS Journal. 275 (1): 138–47. doi:10.1111/j.1742-4658.2007.06184.x. PMC 2573044. PMID 18039331.
  3. Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K (August 1998). "Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal". The Journal of Biological Chemistry. 273 (34): 21790–9. doi:10.1074/jbc.273.34.21790. PMID 9705317.
  4. Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS (August 2002). "Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1)". The Journal of Biological Chemistry. 277 (32): 28909–15. doi:10.1074/jbc.M202588200. PMID 12036956.
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