N-sulfoglucosamine sulfohydrolase

In enzymology, a N-sulfoglucosamine sulfohydrolase (EC 3.10.1.1) is an enzyme that catalyzes the chemical reaction

N-sulfo-D-glucosamine + H2O D-glucosamine + sulfate
N-sulfoglucosamine sulfohydrolase
Identifiers
EC number3.10.1.1
CAS number37289-41-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are N-sulfo-D-glucosamine and H2O, whereas its two products are D-glucosamine and sulfate.

This enzyme belongs to the family of hydrolases, specifically those acting on sulfur-nitrogen bonds. The systematic name of this enzyme class is N-sulfo-D-glucosamine sulfohydrolase. Other names in common use include sulfoglucosamine sulfamidase, heparin sulfamidase, 2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate, and sulphohydrolase). This enzyme participates in glycosaminoglycan degradation and glycan structures - degradation.

This enzyme can also be found at SGSH

References

    • Dietrich CP (1969). "Enzymic degradation of heparin A sulphamidase and a sulphoesterase from Flavobacterium heparinum". Biochem. J. 111 (1): 91–5. PMC 1187498. PMID 5775690.
    • Mahuran D, Clements P, Hopwood J (1983). "A rapid four column purification of 2-deoxy-D-glucoside-2-sulphamate sulphohydrolase from human liver". Biochim. Biophys. Acta. 757 (3): 359–65. doi:10.1016/0304-4165(83)90062-4. PMID 6849981.


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