Mugineic-acid 3-dioxygenase

Mugineic-acid 3-dioxygenase (EC 1.14.11.25, IDS2) is an enzyme with systematic name mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction

(1) mugineic acid + 2-oxoglutarate + O2 3-epihydroxymugineic acid + succinate + CO2
(2) 2'-deoxymugineic acid + 2-oxoglutarate + O2 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2
Mugineic-acid 3-dioxygenase
Identifiers
EC number1.14.11.25
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Mugineic-acid 3-dioxygenase contains iron(II). Mugineic acid is an amino acid excreted by some graminaceous (grassy) plants under conditions of iron deficiency as part of a strategy of solubilizing Fe from the root environment for uptake by the plant. Mugineic acid is closely related to its biochemical precursor, nicotianamine, and to a number of other compounds that also have been identified as phytosiderophores in graminaceous plants: 3-hydroxymugineic acid, 2'-deoxymugineic acid, avenic acid, and distichonic acid. The effectiveness of mugineic acid under iron-deficient conditions is dependent not only upon the iron chelating properties of the Fe-mugineic acid complex itself but also upon the presence of a plant membrane carrier that recognizes and absorbs the Fe-mugineic acid complex almost exclusively.[3]

References
  1. Nakanishi H, Yamaguchi H, Sasakuma T, Nishizawa NK, Mori S (September 2000). "Two dioxygenase genes, Ids3 and Ids2, from Hordeum vulgare are involved in the biosynthesis of mugineic acid family phytosiderophores". Plant Molecular Biology. 44 (2): 199–207. doi:10.1023/A:1006491521586. PMID 11117263.
  2. Okumura N, Nishizawa NK, Umehara Y, Ohata T, Nakanishi H, Yamaguchi T, Chino M, Mori S (July 1994). "A dioxygenase gene (Ids2) expressed under iron deficiency conditions in the roots of Hordeum vulgare". Plant Molecular Biology. 25 (4): 705–19. doi:10.1007/BF00029608. PMID 8061321.
  3. http://www.soils.wisc.edu/~barak/images/mug_frm.htm
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