Methionine S-methyltransferase

In enzymology, a methionine S-methyltransferase (EC 2.1.1.12) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + L-methionine S-adenosyl-L-homocysteine + S-methyl-L-methionine
methionine S-methyltransferase
Identifiers
EC number2.1.1.12
CAS number9027-77-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are S-adenosyl methionine and L-methionine, whereas its two products are S-adenosylhomocysteine and S-methyl-L-methionine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:L-methionine S-methyltransferase. Other names in common use include S-adenosyl methionine:methionine methyl transferase, methionine methyltransferase, S-adenosylmethionine transmethylase, and S-adenosylmethionine-methionine methyltransferase. This enzyme participates in selenoamino acid metabolism. It has 2 cofactors: manganese, and zinc.

References

    • Karr D, Tweto J, Albersheim P (1967). "S-adenosyl methionine: methionine methyl transferase from wheat germ". Arch. Biochem. Biophys. 121 (3): 732–8. doi:10.1016/0003-9861(67)90061-6. PMID 6078098.


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