Macrocin O-methyltransferase

In enzymology, a macrocin O-methyltransferase (EC 2.1.1.101) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + macrocin S-adenosyl-L-homocysteine + tylosin
macrocin O-methyltransferase
Identifiers
EC number2.1.1.101
CAS number79468-52-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are S-adenosyl methionine and macrocin, whereas its two products are S-adenosylhomocysteine and tylosin.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:macrocin 3"'-O-methyltransferase. Other names in common use include macrocin methyltransferase, and S-adenosyl-L-methionine-macrocin O-methyltransferase.

References

    • Bauer NJ, Kreuzman AJ, Dotzlaf JE, Yeh WK (1988). "Purification, characterization, and kinetic mechanism of S-adenosyl-L-methionine:macrocin O-methyltransferase from Streptomyces fradiae". J. Biol. Chem. 263 (30): 15619–25. PMID 3170601.
    • Kreuzman AJ, Turner JR, Yeh WK (1988). "Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis Substrate specificity, enzyme inhibition, and kinetic mechanism". J. Biol. Chem. 263 (30): 15626–33. PMID 3170602.


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