Macelignan
Macelignan (Anwulignan) is a lignan. It can be found in Myristica fragrans, the nutmeg.
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| IUPAC name
(8R, 8′S)-7-(3,4-methylenedioxyphenyl)-7′-(4-hydroxy-3-methoxyphenyl)-8,8′-dimethybutane | |
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| Properties | |
| C20H24O4 | |
| Molar mass | 328.40 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Medical research
One study has shown that macelignan may exert antimicrobial and anticariogenic activity against Streptococcus mutans, but this is not a currently used treatment.[1][2]
Macelignan may also act as an antidiabetic molecule via PPAR signaling. [3]
References
- Dental Caries and Medicinal Plants –An Overview. B. Parimala Devi and R. Ramasubramaniaraj, Journal of Pharmacy Research 2009, 2(11),1669-1675 "Archived copy". Archived from the original on 2011-07-23. Retrieved 2011-08-27.CS1 maint: archived copy as title (link)
- Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans. J.Y. Chung, J.H. Choo, M.H. Lee and J.K. Hwang, Phytomedicine, Volume 13, Issue 4, 13 March 2006, Pages 261-266, doi:10.1016/j.phymed.2004.04.007
- Therapeutic Potential of Peroxisome Proliferators–Activated Receptor-α/γ Dual Agonist With Alleviation of Endoplasmic Reticulum Stress for the Treatment of Diabetes http://diabetes.diabetesjournals.org/content/57/3/737.long
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