MS4A7

Membrane-spanning 4-domains subfamily A member 7 is a protein that in humans is encoded by the MS4A7 gene.[5][6][7]

MS4A7
Identifiers
AliasesMS4A7, 4SPAN2, CD20L4, CFFM4, MS4A8, membrane spanning 4-domains A7
External IDsOMIM: 606502 MGI: 1918846 HomoloGene: 10922 GeneCards: MS4A7
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q12.2Start60,378,485 bp[1]
End60,395,951 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

58475

109225

Ensembl

ENSG00000166927

ENSMUSG00000024672

UniProt

Q9GZW8

n/a

RefSeq (mRNA)

NM_206940
NM_021201
NM_206938
NM_206939

NM_001025610
NM_001276398
NM_027836

RefSeq (protein)

NP_067024
NP_996821
NP_996822
NP_996823

n/a

Location (UCSC)Chr 11: 60.38 – 60.4 MbChr 19: 11.32 – 11.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000166927 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024672 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ishibashi K, Suzuki M, Sasaki S, Imai M (Mar 2001). "Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor". Gene. 264 (1): 87–93. doi:10.1016/S0378-1119(00)00598-9. PMID 11245982.
  6. Liang Y, Tedder TF (Jun 2001). "Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse". Genomics. 72 (2): 119–27. doi:10.1006/geno.2000.6472. PMID 11401424.
  7. "Entrez Gene: MS4A7 membrane-spanning 4-domains, subfamily A, member 7".

Further reading


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