Kynurenine 7,8-hydroxylase
In enzymology, a kynurenine 7,8-hydroxylase (EC 1.14.99.2) is an enzyme that catalyzes the chemical reaction
- kynurenate + AH2 + O2 7,8-dihydro-7,8-dihydroxykynurenate + A
| kynurenine 7,8-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.99.2 | ||||||||
| CAS number | 9029-63-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The 3 substrates of this enzyme are kynurenate, an electron acceptor AH2, and O2, whereas its two products are 7,8-dihydro-7,8-dihydroxykynurenate and the reduction product A.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating). Other names in common use include kynurenic acid hydroxylase, kynurenic hydroxylase, and kynurenate 7,8-hydroxylase. This enzyme participates in tryptophan metabolism.
References
- Taniuchi H, Hayaishi O (January 1963). "Studies on the metabolism of kynurenic acid. III. Enzymatic formation of 7,8-dihydroxykynurenic acid from kynurenic acid". The Journal of Biological Chemistry. 238: 283–93. PMID 13984873.