Joliet Catholic Academy

• James Otteson (Class of 1986) is a philosopher and economist. Currently he is Executive Director of the Eudaimonia Institute, as well as professor of economics and Thomas W. Smith Presidential Chair in Business Ethics, at Wake Forest University. He is also a Research Professor in the Center for the Philosophy of Freedom and in the Philosophy Department at the University of Arizona and a Senior Fellow at The Fund for American Studies in Washington, D.C.[7]

• Melissa McCarthy is an alumni.

• John R Lausch Jr. (Class of 1988), U.S. Attorney for Northern District of Illinois.
• Jack McGuire (Class of 1951), Member of the Illinois House of Representatives

• Joe Benson (Class of 2006) was drafted after his senior year of high school by the Minnesota Twins in the second round (64th overall) of the 2006 MLB draft.[8] Made his major league debut on September 6, 2011 for the Twins. His first major league hit was a single off of Detroit Tigers pitcher Max Scherzer on September 10, 2011.[9] He began the 2012 season with the Twins' Triple-A affiliate Rochester Red Wings and did not return to the majors, ending his MLB career with 17 hits.[10]
• Sean Bergman, former MLB player (Detroit Tigers, San Diego Padres, Houston Astros, Atlanta Braves, Minnesota Twins). A pitcher, he threw a shutout for the Tigers against the Milwaukee Brewers on May 11, 1995. He won 39 games between 1993 and 2000.
• Kevin Cameron (Class of 1998)[11] is a former MLB pitcher who played for the San Diego Padres and the Oakland Athletics, appearing in 69 games.[12] Was rated 72nd in Baseball America's Top 100 prospects and made all-state and all-area selections in 1998. Also set a state playoff record with 20 strikeouts in a game.[13] Cameron was drafted out of high school by the Chicago White Sox in the 1998 MLB Draft, but elected to attend Georgia Tech on scholarship instead.[13] Cameron was drafted again in the 2001 MLB draft by the Minnesota Twins in the 13th round (377th overall pick).
• Mark Grant (Class of 1981) was a Major League Baseball pitcher from 1984–1993 and is now the color commentator for the San Diego Padres.[14] Grant was selected in the first round of the 1981 MLB Draft as the 10th overall selection by the San Francisco Giants.
• Mike Grace, former MLB player (Philadelphia Phillies), pitched for the Phillies from 1995–99, winning 16 games.
• Bill Gullickson (Class of 1977), former MLB pitcher (Montreal Expos, Cincinnati Reds, New York Yankees, Houston Astros, Detroit Tigers). Selected as the second pick of the 1977 MLB Draft, Gullickson spent 14 seasons in the majors, winning 162 games. He led the American League in wins during the 1991 season with 20. Gullickson's 18-strikeout game for the Expos is still a record for that franchise, which is now the Washington Nationals.
• Chris Michalak, former MLB player (Arizona Diamondbacks, Toronto Blue Jays, Texas Rangers, Cincinnati Reds), 1998–2006. He was pitching coach for the Harrisburg Senators, Class AA affiliate of the Washington Nationals, in 2017.
• Jack Perconte, former MLB player (Los Angeles Dodgers, Cleveland Indians, Seattle Mariners, Chicago White Sox) from 1980–86. A second baseman, he had 180 hits and 29 stolen bases during the 1984 Mariners season, batting .294.

• Terry Gannon (Class of 1981) played college basketball at North Carolina State, where he was a member of Jim Valvano's "Cardiac Pack" national championship-winning team in 1983.[15] During his four-year career, (1981–85), he was a two-time Academic All-American and NC State's all-time leading free throw shooter. In 1983, he was the #1 three-point shooter in the nation.[16] After a short basketball career in Europe, Gannon turned to broadcasting on the advice of his coach "Jimmy V."[15]
• Ed Mikan was a professional basketball player in the BAA and its successor, the NBA (1948–54). A member of DePaul's 1945 National Invitation Tournament championship team, he was the fifth overall pick in the 1948 BAA draft.[17]
• George Mikan (Class of 1942) was inducted into the Naismith Memorial Basketball Hall of Fame in 1959. Nicknamed "Mr. Basketball," Mikan played for DePaul University, then for the Chicago American Gears of the National Basketball League (NBL) and the Minneapolis Lakers of the NBL, the Basketball Association of America (BAA) and the National Basketball Association (NBA). Milan won seven NBL, BAA and NBA championships, an All-Star MVP trophy and three scoring titles. He was a member of the first four NBA All-Star and the first six All-BAA and All-NBA teams. Mikan was so dominant that he caused several rule changes in the NBA, among them the widening of the foul lane — known as the "Mikan Rule" — and the introduction of the shot clock.[18] One of the founding fathers of the American Basketball Association, served as the league's commissioner. Played a critical role in the founding of the Minnesota Timberwolves. Mikan made the 25th and 35th NBA Anniversary Teams of 1970 and 1980 and was elected one of the NBA 50 Greatest Players in 1996. Since April 2001, a statue of Mikan shooting his trademark hook shot graces the entrance of the Timberwolves' Target Center.[18]
• Allie Quigley (Class of 2004) currently plays in the WNBA as a member of the Chicago Sky and won the 2014 and 2015 WNBA Sixth Woman of the Year Award. She attended DePaul University and received honors such as Conference USA Freshman of the Year as well as two-time first team all Big East.

• Mike Alstott (Class of 1992) was an NFL fullback and 6-time Pro Bowl selection for the Tampa Bay Buccaneers and was a member of the team that won Super Bowl XXXVII.[19] He also played fullback for the Purdue Boilermakers, where he was three-time MVP and set nearly every school rushing record and several Big Ten Conference ones.[20] Alstott was the 35th overall selection of the 1996 NFL Draft.
• Coby Fleener (Class of 2007) was selected with the second pick of the second round (34th overall) of the 2012 NFL Draft by the Indianapolis Colts. He was the first tight end taken in that draft. Fleener attended Stanford University after becoming an all-conference, all-area, all-state and all-academic honoree during his senior season at Joliet Catholic Academy.[21] He currently plays for the New Orleans Saints.

• Tom Thayer (Class of 1979) was an NFL offensive lineman for the Chicago Bears, and was a member of the team that won Super Bowl XX. Thayer was the 91st overall selection of the 1983 NFL Draft, having played college football for Notre Dame. He is currently a radio color commentator for the Bears.[22]
• Josh Ferguson (Class of 2011) played football at the University of Illinois as a running back. Going undrafted, he was later signed by the NFL's Indianapolis Colts.
• Daniel Eugene "Rudy" Ruettiger (born August 23, 1948) is a motivational speaker who played college football at the University of Notre Dame. His early life and career at Notre Dame was the inspiration for the 1993 film Rudy.

Swimming

• David Sims (Class of 1980) was a member of the 1980 U.S. Olympic Swimming Team in the 1500 meter freestyle. He was a member of the USA National Team from 1980 to 1986. At Stanford University, he was a NCAA All-America from 1981 to 1984.

• Kelly Murphy was Gatorade National Player of the Year in 2008. She played Division 1 volleyball for the University of Florida, where she was a four-time All-American. Murphy represented Team USA in the 2016 Rio de Janeiro Olympics, winning a bronze medal.

• Bob Zak (Class of 1979) is a radio personality who has performed on a variety of stations in the Chicago market including WJRC, WCCQ, WJOL, I-Rock, WKKD, WJTW, WCSJ as well as Chicago's WCFL, WCKG, Star Station, and Y107.9-The 1970s station, among others.