Isotuberculosinol synthase
Isotuberculosinol synthase (EC 3.1.7.9, Rv3378c) is an enzyme with systematic name tuberculosinyl diphosphate diphosphohydrolase (isotuberculosinol forming).[1][2] This enzyme catalyses the following chemical reaction
- tuberculosinyl diphosphate + H2O (13S)-isotuberculosinol + diphosphate
| Isotuberculosinol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.7.9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is present in species of Mycobacterium that cause tuberculosis.
References
- Nakano C, Ootsuka T, Takayama K, Mitsui T, Sato T, Hoshino T (2011). "Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R, S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome". Bioscience, Biotechnology, and Biochemistry. 75 (1): 75–81. doi:10.1271/bbb.100570. PMID 21228491.
- Hoshino T, Nakano C, Ootsuka T, Shinohara Y, Hara T (April 2011). "Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis". Organic & Biomolecular Chemistry. 9 (7): 2156–65. doi:10.1039/c0ob00884b. PMID 21290071.
External links
- Isotuberculosinol+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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