Inositol 2-dehydrogenase

In enzymology, an inositol 2-dehydrogenase (EC 1.1.1.18) is an enzyme that catalyzes the chemical reaction

myo-inositol + NAD+ 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
inositol 2-dehydrogenase
Identifiers
EC number1.1.1.18
CAS number9028-25-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are myo-inositol and NAD+, whereas its 3 products are 2,4,6/3,5-pentahydroxycyclohexanone, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is myo-inositol:NAD+ 2-oxidoreductase. Other names in common use include myo-inositol 2-dehydrogenase, myo-inositol:NAD+ oxidoreductase, inositol dehydrogenase, and myo-inositol dehydrogenase. This enzyme participates in inositol metabolism and inositol phosphate metabolism.

References

    • Berman T, Magasanik B (1966). "The pathway of myo-inositol degradation in Aerobacter aerogenes Dehydrogenation and dehydration". J. Biol. Chem. 241 (4): 800–6. PMID 5905122.
    • Larner J, Jackson WT, Graves DJ, Stamer JR (1956). "Inositol dehydrogenase from Aerobacter aerogenes". Arch. Biochem. Biophys. 60 (2): 352–63. doi:10.1016/0003-9861(56)90437-4. PMID 13292912.
    • Vidal-Leiria M, van Uden N (1973). "Inositol dehydrogenase from the yeast Cryptococcus melibiosum". Biochim. Biophys. Acta. 293 (2): 295–303. doi:10.1016/0005-2744(73)90337-9. PMID 4351258.


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