Hydroxyphenylpyruvate reductase

In enzymology, a hydroxyphenylpyruvate reductase (EC 1.1.1.237) is an enzyme that catalyzes the chemical reaction

3-(4-hydroxyphenyl)lactate + NAD+ 3-(4-hydroxyphenyl)pyruvate + NADH + H+
hydroxyphenylpyruvate reductase
Identifiers
EC number1.1.1.237
CAS number117590-77-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are 3-(4-hydroxyphenyl)lactate and NAD+, whereas its 3 products are 3-(4-hydroxyphenyl)pyruvate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxyphenyllactate:NAD+ oxidoreductase. This enzyme is also called HPRP. This enzyme participates in tyrosine metabolism and phenylalanine metabolism.

References

    • Petersen M, Alfermann AW (1988). "Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase". Z. Naturforsch. C: Biosci. 43: 501–504.


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