Homospermidine synthase

Homospermidine synthase (EC 2.5.1.44) is an enzyme with systematic name putrescine:putrescine 4-aminobutyltransferase (ammonia-forming).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

(1) 2 putrescine sym-homospermidine + NH3 + H+
(2) putrescine + spermidine sym-homospermidine + propane-1,3-diamine
Homospermidine synthase
Identifiers
EC number2.5.1.44
CAS number76106-84-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The reaction of this enzyme occurs in three steps.

References

  1. Tait GH (February 1979). "The formation of homospermidine by an enzyme from Rhodopseudomonas viridis [proceedings]". Biochemical Society Transactions. 7 (1): 199–201. doi:10.1042/bst0070199. PMID 437275.
  2. Böttcher F, Ober D, Hartmann T (1994). "Biosynthesis of pyrrolizidine alkaloids: putrescine and spermidine are essential substrates of enzymatic homospermidine formation". Can. J. Chem. 72: 80–85. doi:10.1139/v94-013.
  3. Yamamoto S, Nagata S, Kusaba K (July 1993). "Purification and characterization of homospermidine synthase in Acinetobacter tartarogenes ATCC 31105". Journal of Biochemistry. 114 (1): 45–9. doi:10.1093/oxfordjournals.jbchem.a124137. PMID 8407874.
  4. Srivenugopal KS, Adiga PR (August 1980). "Enzymic synthesis of sym-homospermidine in Lathyrus sativus (grass pea) seedlings". The Biochemical Journal. 190 (2): 461–4. doi:10.1042/bj1900461. PMC 1162113. PMID 7470060.
  5. Ober D, Tholl D, Martin W, Hartmann T (1996). "Homospermidine synthase of Rhodopseudomonas viridis: Substrate specificity and effects of the heterologously expressed enzyme on polyamine metabolism of Escherichia coli". J. Gen. Appl. Microbiol. 42 (5): 411–419. doi:10.2323/jgam.42.411.
  6. Ober D, Hartmann T (December 1999). "Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 14777–82. Bibcode:1999PNAS...9614777O. doi:10.1073/pnas.96.26.14777. PMC 24724. PMID 10611289.
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