Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) (EC 2.5.1.83, HexPS, hexaprenyl pyrophosphate synthetase, hexaprenyl diphosphate synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units).[1][2][3] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate 3 diphosphate + all-trans-hexaprenyl diphosphate
Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
Identifiers
EC number2.5.1.83
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate.

References

  1. Fujii H, Koyama T, Ogura K (December 1982). "Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components". The Journal of Biological Chemistry. 257 (24): 14610–2. PMID 7174655.
  2. Shimizu N, Koyama T, Ogura K (March 1998). "Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase". Journal of Bacteriology. 180 (6): 1578–81. PMC 107062. PMID 9515931.
  3. Nagaki M, Kimura K, Kimura H, Maki Y, Goto E, Nishino T, Koyama T (August 2001). "Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases". Bioorganic & Medicinal Chemistry Letters. 11 (16): 2157–9. doi:10.1016/S0960-894X(01)00391-2. PMID 11514159.
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