HLA-DR6

HLA-DR6 (DR6) is a broad-antigen serotype that is further split into HLA-DR13 and HLA-DR14 antigen serotypes.

Illustration of HLA-DR

Serology

DR13, DR6 and other serotype recognition of some DRB1*13 and DRB1*14 alleles[1]
DRB1*DR13 DR6DR14Sample
allele%%%size (N)
1301811413788
1302741723081
130369102948[2]
130487127
13055412305[3]
1306789
1307>501
130845559
1310>755
DRB1*DR14DR6DR13N
1401741431942
140261139204
14037212237
140479880[4]
1405861058
1406371522117
14079010
1408254[5]
1410>754

DR6 serological reactivity is relatively poor compared to other serological tests for DR antigens. Compare to DQ2 or DR7.

Disease associations

DR13 and DR14 share a common association to myastenia gravis.[6]

Allele groups

HLA-DRB1*13 and HLA-DRB1*14 encode serotypes of DR6.

References

  1. derived from IMGT/HLA
  2. DR12 - 3%, DR11 - 3% DR5-2%
  3. DR12 - 6%, DR11 - 7% DR5-4%
  4. DR1404 - 3%
  5. DR4 - 25%
  6. Shinomiya N, Nomura Y, Segawa M (2004). "A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan". Clin Immunol. 110 (2): 154–8. doi:10.1016/j.clim.2003.10.004. PMID 15003812.
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